Biotics Research


Sculacia® supplies an all natural, patented, proprietary blend of two classes of specific compounds; free-B-ring flavanoids and flavins. Sculacia® has been demonstrated to inhibit both COX-2 and 5-LO enzymatic activity, thereby decreasing the metabolism of arachidonic acid (AA) to prostaglandins, thromboxanes, and leukotrienes. Additionally, Sculacia® specifically decreases peroxisome proliferator-activated receptor gamma (PPARγ), a key gene expression regulator, which results in the downregulation of gene expression for COX-2, 5-LO,TNFα, IL-1β, IL-6, but not COX-1.

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