Sculacia supplies an all natural, patented, proprietary blend of two classes of specific compounds; free-B-ring flavanoids and flavins. Sculacia has been demonstrated to inhibit both COX-2 and 5-LO enzymatic activity, thereby decreasing the metabolism of arachidonic acid (AA) to prostaglandins, thromboxanes, and leukotrienes. Additionally, Sculacia specifically decreases peroxisome proliferator-activated receptor gamma (PPARγ), a key gene expression regulator, which results in the downregulation of gene expression for COX-2, 5-LO,TNFα, IL-1β, IL-6, but not COX-1. In a randomized, double-blind, controlled study, using the Western Ontario and McMaster Universities Osteo-Arthritis Index (WOMAC), a protocol reviewed and approved by an IRB board from the University of Montreal, significant improvement was documented for discomfort, stiffness and function as compared to placebo.
One (1) capsule one (1) to two (2) times each day as a dietary supplement or as otherwise directed by a healthcare professional.
Sculacia Proprietary Blend; Chinese Skullcap Extract (Scutellaria baicalensis) (root), Cutch Tree Extract (Acacia catechu) (heartwood & bark). Sculacia proprietary extract is protected by U.S. Patents No. 7,192,611 and No. 7,108,868 as well as other pending patents.
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